Poster Abstracts
Uric acid is elevated in children with obesity and decreased after a lifestyle-induced weight loss intervention.
Authors:
Rasmus Møller Jørgensen ,
Steno Diabetes Center Aarhus, Aarhus University Hospital, Denmark
Health, University of Aarhus
Dept. of Pediatrics, Randers Regional Hospital, DK
Bjarke Bøttger,
Steno Diabetes Center Aarhus, Aarhus University Hospital, Denmark, DK
Esben Thyssen Vestergaard,
Steno Diabetes Center Aarhus, Aarhus University Hospital, Denmark
Dept. of Pediatrics, Randers Regional Hospital
Dept. of Clinical Medicine, University of Aarhus, DK
Britta Kremke,
Dept. of Pediatrics, Randers Regional Hospital, DK
Rikke Frederiksen Bahnsen,
Dept. of Pediatrics, Randers Regional Hospital, DK
Bent Windelborg Nielsen,
Dept. of Pediatrics, Randers Regional Hospital, DK
Jens Meldgaard Bruun1.4
Steno Diabetes Center Aarhus, Aarhus University Hospital, Denmark
Dept. of Clinical Medicine, University of Aarhus, DK
Abstract
Introduction: Childhood obesity may be associated with continuous obesity into adulthood and development of obesity-related comorbidities. In adult, studies have demonstrated an association between circulating levels of uric acid (UA), body mass index (BMI), and the development of type 2 diabetes and the metabolic syndrome. The aim of the current study was to investigate the relationship between UA in children and adolescents with obesity, involved in a municipality-based lifestyle intervention.
Methods: One hundred and seventy-one children (age 4-18), with a body mass index standard deviation score (BMI-SDS) of +2 or higher were included in a multifactorial lifestyle intervention study. The intervention was a collaboration between the children, parents, community healthcare workers and the regional hospital. The children who participated, were annually invited to the hospital for anthropometrics, blood samples and DEXA-scans for up to 3 years. In between, the children were seen up 8 times per year by a community healthcare worker. Eighty-nine children were included for follow-up analysis.
Results: After a follow-up of 20.7 ± 9.4 months a reduction in BMI-SDS of -0.34 ± 0.53 (p < 0.01) was observed. In parallel, UA was found to be positively associated with changes in BMI-SDS. UA levels decreased in the 76 children who lost weight during the intervention, conversely, UA increased in the 23 children who gained weight during the intervention (p < 0.01 between groups).
Conclusion: Interestingly, UA was found to correlate with measures of childhood obesity, and for the first time this study demonstrates a positive relationship between weight reduction in children with obesity and changes in UA.
Implications for applicability: This study implies that UA may be used as a marker when assessing health conditions (i.e. BMI-SDS) in children with obesity.
How to Cite:
Møller Jørgensen R, Bøttger B, Vestergaard ET, Kremke B, Bahnsen RF, Nielsen BW, et al.. Uric acid is elevated in children with obesity and decreased after a lifestyle-induced weight loss intervention.. International Journal of Integrated Care. 2022;22(S3):32. DOI: http://doi.org/10.5334/ijic.ICIC22272
Published on
04 Nov 2022.
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