Background: Most current care models are disease- or symptom-focused and mostly do not account for the individual needs of patients with chronic diseases. The aim of this study was to develop an innovative, evidence-based and expert-based practice model for the management of patients with type 2 diabetes mellitus.
Method: An iterative approach was used combining systematic literature search with qualitative methods, including a standardised survey of experts in chronic care (n = 92), an expert workshop of professionals (n = 22) and a multilingual online survey (n = 659). Using three consensus meetings involving researchers, policy makers and experts in chronic care, a limited number of core components and care recommendations was set up to develop a new chronic care model.
Results: The developed ‘MANAGE CARE MODEL’ includes aspects of the health and social care system, resources derived from the living environment, aspects of health promotion and prevention, as well as an expanded understanding of improved outcomes as an integral part of chronic care.
Conclusion: The MANAGE CARE MODEL provides guidance for the development and implementation of chronic care programs, regional networks and national strategies. Future research is needed to validate the model as an instrument of regional chronic care management.
A growing number of EU citizens suffers from diabetes, posing an emerging health, social and economic burden in the EU . This burden is mostly driven by type 2 diabetes mellitus (T2DM), which is increasingly diagnosed at younger age and leads to a rising number of adults with T2DM aged 65 and older . Due to these rising numbers in diabetes prevalence a growing number of patients faces accompanying comorbidities as well as complex needs [2, 3, 4, 5]. However, many care systems are historically built on separate sectors (health vs. social care, in- vs. outpatient care). This traditional acute and episodic focus of care is inadequate to effectively meet the complex needs of patients as it increases the risk of care fragmentation and loss of information [6, 7]. Although these circumstances are repetitively part of health policy initiatives [8, 9], there is still an institutional and regulatory separation between health and social care services, as well as between ambulatory and inpatient care .
Integrated care is said to improve outcomes of care by linking services of providers along the continuum of care and thus overcoming issues of fragmentation . Back in 1996, Ed Wagner developed the Chronic Care Model (CCM), which became a cornerstone to improve care delivery for chronically ill patients. The CCM comprises the following six components: (1) community, (2) health system, (3) self-management support, (4) delivery system design, (5) decision support and (6) clinical information systems . Ever since, different initiatives developed new models targeting specific weaknesses of the initial CCM.
However, recent analysis uncovered that the understanding of established models’ impact on chronic disease management is limited . This is especially true for the effectiveness and applicability of chronic care models in different populations and settings . Additionally, validated outcome measures, targeting the heterogeneous population of elderly patients, the community they live in as well as their caregivers  are needed to improve our understanding of the dynamic and diversified shape of integrated care concepts . Consequently, EU-wide strategies and recommendations for regional implementation of target-group specific chronic care models are still lacking. However, there is a strong need for such guidance as most health systems still (unintentionally) incentivise the treatment of each multiple disorder separately, instead of approaching comorbid patients holistically . Most current care models and treatment guidelines are disease-or symptom-focused and do not include specific instructions on how to prioritise, e.g. diabetes treatment relative to that of other comorbidities and the functional status of patients [13, 17].
The present study makes use of published results belonging to the same EU-funded project MANAGE CARE – Active Ageing with Type 2 Diabetes as Model in the Development and Implementation of Innovative Chronic Care Management Models in Europe. The project included 37 partner institutions like research facilities and national diabetes associations from 17 different countries in Europe.
A systematic review and meta-analysis on the effectiveness of the CCM in diabetes care identified eight cluster randomised controlled trials (RCTs) (9,529 patients). However, besides the limited evidence on the effectiveness derived from RCTs and a wide range of outcome measures, only small effects of European multifaceted diabetes care patient outcomes were identified .
Additionally, a standardised survey of experts in chronic care (n = 92) to analyse existing chronic care programs focusing on effective and missing components, an expert workshop (n = 22) to define unmet needs and priorities of elderly patients with T2DM, and a multilingual online survey (n = 650) to validate and rank these needs were conducted. Financial support, case management and the consideration of social care were identified as potential areas for improvement in current care models. The expert workshop revealed a number of 150 patient needs, which were grouped into 13 needs dimensions. An online survey was conducted to rank these grouped needs dimensions using an analysis of central tendency (M). Patient education was rated as the most important patient need for both patients (M = 4.23, SD = 2.956) and health care professionals (HCP) (M = 4.88, SD = 3.171) in total, followed by prevention and education and knowledge of HCPs .
The aim of this study was to develop an innovative, evidence-based and expert-driven practice model for chronic care management of T2DM, addressing the specific needs of patients with diabetes.
An iterative approach combining systematic literature search with qualitative methods and a number of three consensus meeting was used. Figure 1 illustrates the iterative process from gathering data to developing the final model, highlighting the applied methods and their objectives. The process includes steps of previously published analyses and covers the (A) state-of-the-art assessment, (B) analysis of model components and unmet needs, as well as the (C) model development.
A literature review was carried out in Medline via PubMed and was complemented by a hand search of global chronic care programs and their components. The search combined long term/chronic care with disease management related terms [Annex 1]. Records were included if they were published after the year 2000, and were written in German or English. Studies were included if they reported on the development of models and programs targeting patients with chronic diseases. Additionally, records were included if they reported on the effectiveness or quality of such models. A standardised protocol was used to summarise relevant information on the identified models. This included aims, target populations, interventions, key stakeholders, features/dimensions and outcomes, which were summarised and structured in a matrix. This matrix was used as a starting point for discussions and expert workshops within the study group (Table 1). Afterwards hand searches were used to identify evidence on the quality and effectiveness of the models and their components.
|#||Study design; Objective||Implications and recommendations for the final model|
to identify chronic care programs and structure their components
|Rare/missing data on the effectiveness and quality of chronic care programs and their components|
Systematic Review on effectiveness of CCM ;
to systematically identify studies of diabetes care assessing the effect of interventions addressing all six components of the CCM
Limited evidence on the effectiveness of implementing all CCM-components simultaneously in older patients in Europeand lack of data to understand the intensity of the intervention.
Patients with screen-detected T2DM and patients with newly diagnosed T2DM showed improved effects on HbA1c → focus on prevention and health promotion
Standardised survey (n = 92) of experts in chronic care ;
to analyse existing chronic care programs focusing on effective, problematic and missing components
|“Financial support” (no tangible incentives, scarcity of funding, and no refund) regarded as missing in current care programs.
Case management and quality management should be an integral part of chronic care management.
The incorporation of social services and informal social support, especially for people with complex health and social care needs, is strongly recommended.
Expert workshop (n = 22) of HCP and experts of a European funded research project MANAGE CARE ;
to define a limited number of unmet needs and priorities of elderly patients with T2DM and comorbidities
|Evidence-based chronic care must be available and affordable to patients.
Cooperative systems are conducive to better chronic care management, including care navigation, care planning and risk stratification.
Measures to evaluate the effectiveness, quality and feasibility of careusing predefined Shared Outcome Frameworks (triple aim) without being limited to medical outcomes need to be implemented.
Multilingual online survey of patients and health care providers (n = 650) ;
to validate and rank the identified patient needs
|Chronic care must address individual patient needs and preferences as much as medical treatment objectives.
Education of patients as well as prevention and health promotion are integral to chronic care management.
Pro-active communication with the patient should be supported.
Previously published data gathered from a multilingual online survey (n = 650) to validate and rank unmet needs from the perspective of both patients and health care professionals (HCP)  were again evaluated to identify differences in the priorities from the two groups. Mann–Whitney U-test was used to analyse ranks and medians using SPSS for Windows version 23.0 (SPSS, Chicago, IL). Boxplots were used to illustrate the central tendency and spread in those ratings significantly differing between patients and HCPs.
The final model was developed following the principles of Stachowiak, indicating that models are a mapping, a reduction and therefore a pragmatic tool . Three consensus meetings in February, April and May 2016 were set up to iteratively develop the model using feedback of the MANAGE CARE Study Group. This is in line with previous consensus meetings [21, 22, 23]. The extensive list of unmet needs was reviewed by the MANAGE CARE Study Group to identify requirements and potential dimensions for the new model. A limited number of core components to be included in the final model was defined, discussed and merged. Three meetings followed a standardised structure. First, the evidence-informed development of the model was described, afterwards the latest changes were presented and subsequently, the current version of the model was reviewed and commented by the participants. The meetings were moderated by one of the authors. As the three meetings were part of workshops of the same project, the participants were slightly changing between the meetings. By combining several feedback loops within the MANAGE CARE Study Group, components of the final model were specified. Renaming of key dimensions and sub-dimensions was supported by further explanations using exemplary application scenarios. These aspects were summarised in a technical handbook describing the developed model and its application. Between the meetings, both attendees and not attending partners were invited to comment on the revised version of the model. During the final meeting, informal consensus was reached.
The literature review identified 24 health care models from six countries; USA (n = 11), Australia (n = 5), Canada (n = 5), Great Britain (n = 1), Germany (n = 1), and Mexico (n = 1) (annex 2). The expanded version of the chronic care model (eCCM) developed by Barr et al. argues that the CCM is inadequate to proactively cover the heterogeneity and complexities of prevention and health promotion going beyond clinical preventive services [24, 25]. Additionally, the authors suggest a stronger focus on supportive communities and public health policies . Other models include the Innovative Care for the Chronic Conditions (ICCC)  designed for chronically ill people in low- and middle-income countries, the Improving Chronic Illness Care (ICIC)  having a strong focus on integrated practice guidelines, the Stanford Model [28, 29, 30] designed to enhance regular treatment and disease-specific education in a community setting, and the Transitional Care Model as a nurse-led intervention model [31, 32]. Results of the chronic care matrix illustrated a gap in terms of missing evaluations on successful, not successful and missing components of health care models.
The ranked needs “Education of patients” (Mpat= 4,23; MHCP = 4.88; p < 0.01), “Health promotion and all kinds of prevention” (Mpat = 4,28; MHCP = 5.12; p < 0.01), “Communication with the team and with the patient” (Mpat = 5.59; MHCP = 6.26; p < 0.01) and “Availability of services related to information infrastructure” (Mpat = 7.29; MHCP = 8.27; p < 0.001) are significantly more important to patients compared to HCPs (Figure 2) .
Table 1 indicates the implications and recommendations for the final model derived from the iterative process, including the literature review on chronic care programs, the previously published systematic review , and the mixed-method approach to identify and rank patients’ needs from different perspectives . The recommendations resulting from the methodological steps 1 to 5 (Table 1) were used as guiding principles to develop the prototype of the model which was later assessed and further developed during three consensus meetings.
The consensus-building process as well as the numbers and backgrounds of their attendees are presented in Table 2. Overall, 30 project partners actively contributed to the consensus meetings. The majority was active in research and academics (n = 18). Employees of a European association (n = 4), national associations (n = 4), a local diabetes educator and a CEO of a regional chronic care network were also participating. Thirteen took part in more than one of the consensus meetings (two meetings n = 7; all three meetings n = 6).
|Date, place||Overall number of participants||Number of participants per country|
|Berlin, February 2016||10||Germany (n = 4); Greece (n = 2); EU (n = 2); Belgium (n = 1); Poland (n = 1)|
|Athens, April 2016||14||Greece (n = 5); Germany (n = 3); EU (n = 1); Belgium (n = 1); Poland (n = 1); Portugal (n = 1); Lithuania (n = 1); Finland (n = 1)|
|Barcelona, May 2016||24||Germany (n = 8); Greece (n = 4); Serbia (n = 3); Austria (n = 2); EU (n = 2); Portugal (n = 2); Belgium (n = 1); Lithuania (n = 1); Finland (n = 1)|
The following changes were applied after the presentation of the prototype of the model during the first consensus meeting:
During the second meeting, the participants again called for a stronger focus on prevention and health promotion, as this was one core result of the analysis of patient needs . The adapted target group of “citizens” was considered as too broad. Consequently, the target group of the model was changed to “patients with diabetes (risk)”. Finally, the outcome entities included in the “triple aim”  were added to the category of “Improved Managed Care”.
In the third meeting, a definition of the chronic care teams was considered as useful. Before agreeing on the final model, the category of “Improved Managed Care” was slightly changed to “Improved Integrated Care”. This change was deemed necessary as the model intends to improve quality of chronic care in all three quality domains; structure, process and outcome . As case management is defined as a collaborative process to assess, plan, implement, coordinate, monitor and evaluate the options and services required to meet an individual’s health needs , this integration of patient needs was added in the final category. Finally, the participants argued, that although the model targets specific needs of patients with diabetes (risks), the model needs to be applicable in different health systems and settings.
Based on the previously published research [18, 19], the presented results and the consensus-building process, the MANAGE CARE Study Group decided to include seven dimensions and further sub-categories in the final model (Figure 3), including (1) Care Delivery Strategy, (2) Participation, Prevention and Health Promotion, (3) Health and Social Care System, (4) Health Professionals, (5) Living Environment and Broad Community Engagement, (6) Patients with Diabetes (Risk) and (7) Improved Integrated Care. The MANAGE CARE Model (MCM) is a care-focused model, which incorporates assessments of individual needs to continuously adjust care objectives. According to the salutogenetic focus of the model, an improvement of outcomes is conceptualised by changes in terms of medical, social, lifestyle-related and economical aspects. The model is intended as an orientation framework to guide the development and implementation of regional care models.
The MCM advocates a Care Delivery Strategy including six management sub-dimensions enabling responsible clinical, referral/discharge, information, financial and quality management in highly differentiated health systems. There is a growing necessity to balance clinical recommendations with the needs of elderly with T2DM. The development of care delivery strategies should aim to involve multiple disciplines to set up and deliver specialized and preventive care services for people with chronic conditions . To support an effective development and implementation of integrated care pathways, agreements on the whole care continuum are recommended. This includes, among others:
Care Delivery Strategies are supposed to integrate Information and Communication Technologies (ICT), which facilitate sharing information and virtually linking primary and secondary care (e.g. electronic referrals, shared electronic medical records). Joint commissioning of services should be introduced for common transversal targets between primary and secondary care in order to facilitate integrated care. For example: the rate of 30 day readmissions could be a common transversal indicator where primary and secondary care may be collaboratively accountable . Clinical leadership should be promoted and developed at territories and counties involving them to work together with health authorities constructing integrated care pathways.
The holistic understanding of health and social care characterises the MCM and includes aspects of participation, prevention, health promotion and public health [24, 38, 39]. This includes both individual level and population-based lifestyle interventions [40, 41]. The systematic review by Bongaerts et al. reported a higher potential for newly diagnosed patients . Similarly, other studies suggest that low-risk diabetic patients can benefit from integrated healthcare management programs, including a first health specialist assessment at a diabetes service and a coordinated care approach managed by GPs , which is again supporting early detection of patients at risk.
The integration of both the health and social care system is intended to improve the access to vulnerable and high-risk groups of T2DM. This includes social care system coverage of a population through taxes and social charges. It provides guidance for an integrated health and social care system to improve care by combining medical and social needs. The following recommendations may guide this process:
The MCM is based on an equal participation and collaboration of HCPs, the living environment and the individual citizen. This should be supported by transparent case management, shared-decision making and agreements to jointly develop, carry out and evaluate a productive and targeted interaction. Clinical/professional leadership at the level of counties, regions and municipalities should be supported by collaborators like health authorities to construct regional integrated care pathways. Leaders should be included in the commissioning process (e.g. England – formal “Clinical Commissioning Groups” [CCG]) to support contracts with secondary care.
Chronic disease management, including self-management support for the individual patient, should be carried out by qualified health professionals with adequate experience of care. Their work should be supported by local “integrated clinical/care pathways”, representing a regional agreement of multi-professional experts, clinical leaders and services from both the acute and the primary health care sector. This should also include standards for quality monitoring. Individual care plans appropriate to age, clinical needs, cognitive function, level of frailty, physical level, basic, (psycho-) social and emotional determinants should be developed in collaboration with the patient and informal caregivers. The established phases of case and care management will be used to guide the shared-decision making .
The MCM uses the full potential and resources of the individual and his living environment (community and informal caregivers). The intention to closely connect the patient and the HCP with the patient environment is based on a strong need to incorporate community-based resources. Supporting local partnerships has the potential to integrate family and neighbourhood as well as communities support in the holistic care of the patient [44, 45]. This also strengthens the “living with diabetes” approaches which usually go beyond the self-management of disease-specific symptoms and comorbidities. Additionally, effective local area partnerships with self-help groups, leisure facilities or services supporting the daily living (e.g. transportation to appointments) increase patient autonomy. Such engagement should be culturally appropriate and tailored to the individual needs and priorities of the patient.
By assessing the individual needs, health risks, health literacy, and preferences, the MCM focusses on individuals at risk, patients with pre-diabetes and manifest T2DM. This individualised perspective enables to include socioeconomic factors, as well as social, psychological and cultural determinants of health and well-being.
The dynamic relation of the three dimensions, health professionals, living environment and broad community engagement and patients with diabetes (risk), is situated in the centre of the MCM. The aim is to provide a productive and targeted interaction. Stratification is applied to classify different levels of needs and priorities of complex diabetic patients. This applies to all aspects of individualised chronic disease management in T2DM patients including diabetes education, self-management support, case management as well as disease management [46, 47].
The MCM summarises diversified outcomes to evaluate the productive and targeted interaction. It is important to notice that the MCM evaluates more than just medical conditions and goes beyond balancing the triple aim of (1) Experience of Care, (2) (Population) Health Outcomes and (3) Cost-Effectiveness . Based on the salutogenetic nature of the model, indicators need to be developed and applied covering aspects of awareness, health information seeking behaviour, participation and reduction of risk factors. Joint Commissioning of services and Shared Outcome Framework should be developed by all key stakeholders involved in patient care.
Starting with T2DM as a chronic care example, the MANAGE CARE Study Group developed an innovative chronic care model. This MCM addresses the specific needs of elderly populations being increasingly affected with chronic diseases as well as challenges given by the changes in the health care systems and financing structures in the European countries [8, 10].
Both, the literature review and the previously conducted systematic review  found only limited evidence on successful, not successful and missing components of the CCM developed by Wagner et al. This is in line with a systematic review on the effectiveness of chronic care models by Davy and colleagues revealing that such models consist of a variety of components. The authors concluded that it was not possible to retrieve which elements or combinations were associated with increased benefits for patients or professionals . Although the CCM defines essential elements which should be implemented to support chronic care patients, it lacks important information on how to handle multimorbidity in the implementation process. They underline that future care models need to account for the dynamic interaction of the model with the everyday life of patients. As such, evaluation of models should consider patient-centered outcomes, the experience of care and resources needed to implement the model .
The developed MCM builds on the widely implemented CCM and his expanded version (eCCM) while considering the described weaknesses. While Wagners’ CCM includes the “delivery system design” , our MCM changed this element to “care delivery strategy” as the identified evidence and the expert-driven recommendations favour regionally concerted approaches. This includes the identification of relevant disciplines to be involved, defining their responsibilities and jointly pre-defining care pathways as well as quality indicators to be used for the overall chronic care management.
Our MCM also makes use of important elements of the patient-centered medical home model (PCMH), like being team-based, patient-centered, coordinated, and community-oriented . However, the developed MCM puts a stronger emphasis on prevention and supports an active approach to patients at risk for T2DM.
The MCM focuses on both the health and the social care system, as this was strongly suggested during the standardised survey and the expert workshop . Increasing staff involvement at the social context level may minimise barriers due to lacking communication and cooperation . This may be accompanied by joint health and social care funds . However, there is a strong need for evidence derived from complex intervention evaluation methodologies in diverse health and social care contexts .
A meta-regression on interventions designed to improve outpatient care of T2DM patients revealed that case management and team changes were associated with the largest pooled reductions in HbA1c values . As disintegrated care originating from HCPs working in isolation and insufficient knowledge of HCPs was identified as a severe limitation of the original CCM , we include case and care management delivered by experienced HCPs in our model.
While the CCM is the most evaluated care model, Self-Management Support is the most frequent CCM intervention to be associated with statistically significant improvements, predominately for diabetes and hypertension . In addition to self-management support, programs based on collective empowerment in T2DM showed positive effects on clinical as well as behavioural outcomes, and lead to improved self-care . However, Elissenet al. summarise that a better understanding is needed to define what encourages both patients and HCPs to engage in productive interactions . Therefore, a targeted interaction based on integrative and case management approaches was included in the MCM. The MCM also focusses on structured education of patients and HCPs. However, recent analysis uncovered a gap of educational interventions on chronic care for HCP .
Barriers derived from a lacking support from family, friends or the community as well as limited considerations of social determinants may impact chronic care outcomes . Therefore, informal care and community engagement were included in the final MCM. Using resources derived from the living environment and the community of patients when implementing the CCM have shown positive results in terms of clinical and behavioural outcomes [26, 60]. Similarly, recent evidence suggests that task shifting from physicians to community-based health workers, nurses [61, 62] and pharmacists may be of benefit, especially in rural areas [41, 63].
Evaluating the benefit of care models is complex and challenging. Yet, the majority of interventions are not sufficiently adapted to the CCM, which is further worsened by a low methodological quality . Studies including balanced measures on multiple performance dimensions are sparse. There is a strong need to consider integrated care settings and their specific context factors . More consistent outcome assessment frameworks are needed. Measurements of outcomes at the health system level is rare, at the population or community level even more missing . Although (informal) caregivers are frequently involved in chronic care, specific outcome measurements targeting family members or friends are missing .
The developed MCM uses the triple aim perspective as a starting point for evaluation . In 2012, a fourth dimension – improving the work life of health care providers – was added to also take the changing expectations to primary care systems and regional shortage of primary care services into account . Evidence on general cost efficiencies of integrated care models , and their effectiveness carried out in primary as well as social care settings is limited . This is also supported by Busetto et al. calling for intermediate outcome measurements allowing to measure outcomes of specific intervention types .
The developed model is in line with the working definition of “integrated care” as “the management and delivery of health services such that people receive a continuum of health protection, health promotion, disease prevention, diagnosis, treatment, long-term care, rehabilitation and palliative care services through the different levels and sites of care within the health system, and according to their needs” . One important challenge refers to the need for an evaluation of chronic care models in different populations and settings, as there is an unexplained heterogeneity of CCM interventions . As such, future research needs to uncover patient profiles which benefit most from specific interventions, whilst having a stronger emphasis on patients with multiple chronic conditions . On the other hand, HCPs should also be involved in participatory research initiatives in order to include their perceptions on integrated care barriers [7, 73, 74]. Context, mechanisms and outcomes of multifaceted care needs to be part of future research in diabetes care . Other groups call for more research on the implementation of chronic care models in primary care setting with emphasize on self-efficacy, clinical decision making and organisational capacity [75, 76].
Validation studies and evidence focusing on the implementation of the model are needed to gain insights on its applicability and limitations. Both research priorities should take into account the characteristics of the health care systems as well as permutations of mixed systems . This includes country-specific responsibilities of different HCPs (such as hospital-physician relationships or primary care providers as gatekeepers for patients with comorbidities ), managed clinical networks, as well as heterogeneous patient populations. This is especially needed, as most evaluation studies originate from the US . A recent analysis of Baptista et al. suggested that implementing single elements of the CCM may not be sufficient to improve clinical outcomes . As such, organisational readiness and an active approach are drivers to achieve improved outcomes . For the MCM, data on the association of single categories, and their overall effects are needed.
This validation process may benefit from recent quality frameworks, such as the Development Model for Integrated Care (DMIC) , an improved understanding of linking patients’ quality of life with case management interventions  and a more evidence-based analysis of measurements to evaluate integrated care initiatives . Other recently developed models, such as the SELFIE framework for integrated care strongly focus on concepts of multimorbidity grouped at micro-, meso-, and macro levels, which may further guide the validation process . Based on a systematic literature review  and intense discussions, the Multimorbidity Care Model was developed by a pan-European collaborative initiative . The authors also call for validation studies in real life settings.
One strength of the present study is the iterative combination of different methodological steps, including a previously published systematic review, as well as surveys of experts and patients, and consensus meetings to develop a new model for the treatment of T2DM. That way, an evidence-based as well as expert-driven MCM using T2DM as a starting point was developed. The iterative mixed-method approach, especially the combination of systematic research with different qualitative methods, is another strength of our overall design.
The model has not been validated yet. Theoretical and practical validation studies using different health systems, regions and settings as well as heterogeneous target populations are needed.
Based on an evidence-based and expert-driven state-of-the-art assessment, knowledge and evidence on existing disease management models and on the needs of elderly people with T2DM was used to develop the MCM. The model has been designed to guide the development and implementation of individualised chronic care models.
Future research is needed to implement and validate the model as an instrument of regional chronic care management.
The additional files for this article can be found as follows:Annex 1
List of identified models and programs with countries. DOI: https://doi.org/10.5334/ijic.4646.s1Annex 2
Table 3: Chronic care recommendations derived from a multi-professional expert workshop guiding the final model. DOI: https://doi.org/10.5334/ijic.4646.s2Annex 3
Tables 4 and 5: Dimensions, sub-dimensions and examples derived from the literature review. DOI: https://doi.org/10.5334/ijic.4646.s3
The data presented in this article were collected in the EU-funded project MANAGE CARE (“Active Ageing with Type 2 Diabetes as Model for the Development and Implementation of Innovative Chronic Care Management in Europe”; 2012 12 03).
We acknowledge Open Access Funding by the Publication Fund of the TU Dresden.
Three anonymous reviewers.
The authors have no competing interests to declare.
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