Start Submission Become a Reviewer

Reading: Integrated Care Planning for Cancer Patients: A Scoping Review


A- A+
Alt. Display

Research & theory

Integrated Care Planning for Cancer Patients: A Scoping Review


Anum Irfan Khan ,

Institute for Health Policy Management and Evaluation, University of Toronto, Toronto, ON, CA
X close

Erin Arthurs,

Cancer Care Ontario, Toronto, ON, CA
X close

Sharon Gradin,

Cancer Care Ontario, Toronto, ON, CA
X close

Marnie MacKinnon,

Cancer Care Ontario, Toronto, ON, CA
X close

Jonathan Sussman,

Department of Oncology, McMaster University, Hamilton, ON, CA
X close

Vishal Kukreti

Cancer Care Ontario; and Princess Margaret Cancer Centre, University Health Network, Toronto, ON, CA
X close


Introduction: There has been a growing emphasis on the use of integrated care plans to deliver cancer care. However little is known about how integrated care plans for cancer patients are developed including featured core activities, facilitators for uptake and indicators for assessing impact. 

Methods: Given limited consensus around what constitutes an integrated care plan for cancer patients, a scoping review was conducted to explore the components of integrated care plans and contextual factors that influence design and uptake. 

Results: Five types of integrated care plans based on the stage of cancer care: surgical, systemic, survivorship, palliative and comprehensive (involving a transition between stages) are described in current literature. Breast, esophageal and colorectal cancers were common disease sites. Multi-disciplinary teams, patient needs assessment and transitional planning emerged as key features. Provider buy-in and training alongside informational technology support served as important facilitators for plan uptake. Provider-level measurement was considerably less robust compared to patient and system-level indicators. 

Conclusions: Similarities in design features, components and facilitators across the various types of integrated care plans indicates opportunities to leverage shared features and enable a management lens that spans the trajectory of a patient’s journey rather than a phase-specific silo approach to care. 

How to Cite: Khan AI, Arthurs E, Gradin S, MacKinnon M, Sussman J, Kukreti V. Integrated Care Planning for Cancer Patients: A Scoping Review. International Journal of Integrated Care. 2017;17(6):5. DOI:
  Published on 13 Nov 2017
 Accepted on 12 Sep 2017            Submitted on 26 Oct 2016


Cancer patients utilize a wide range of services from multiple providers across settings at various points during their cancer journey, including oncologists, non-cancer specialists, primary care physicians, nurses, pharmacists, physiotherapists and social workers [1]. Given the high cost and complexity of their evolving needs from diagnosis to either survivorship or palliative care, cancer patients require care that is integrated across providers (medical, nursing and allied-health practitioners) and settings over time [1, 2, 3].

Given the diverse range of providers and settings involved in caring for cancer patients [4, 5], there has been a strong emphasis on the use of care plans [6, 7] to support care management in cancer patients [8, 9, 10, 11]. Care plans are seen as tools to organize care processes [12], monitor variance and outcomes [13], facilitate communication between providers, and promote adherence to best clinical evidence [12, 13, 14]. However there is currently limited consensus around a definition for the concept of ‘care plans’ and related constructs including care pathways, clinical pathways, care maps, individualized care plans, and care protocols etc., which are often used interchangeably in the literature [7, 15, 16, 17]. For the purposes of this review, the term ‘care plan’ will be used to refer to these above-mentioned terms.

Existing literature indicates that the use of care plans across a variety of diseases and settings, has helped reduce in-hospital complications [15, 18], enhanced communication between providers, and improved the quality and efficiency of care [12]. But much of the existing work around care planning pertaining to cancer patients has either focused exclusively on the clinical elements of care, i.e., adherence to evidence-based guidelines around surgical and diagnostic procedures etc. [19], or has targeted individual stages in the cancer trajectory (i.e., survivorship or palliative care) [20] rather than using a patient-centered or service delivery lens to inform the integration of care across the continuum. As such little is known about how integrated care plans for cancer patients are developed and implemented, what activities they feature and which organizational and system-level factors enable their uptake.

In the absence of consensus around what constitutes an integrated care plan for cancer patients, a scoping review was conducted to explore the key components of integrated care plans, identify facilitators and barriers associated with their use and examine the indicators that have been utilized to assess their impact. Scoping reviews are commonly used to understand the existing breadth of research on a topic, identify gaps in existing literature and assess the need for further research inquiry [21].


A cursory review of grey and peer-reviewed literature was initially conducted to better understand existing terminology and develop a definition of an ‘integrated care plan’ for cancer patients. The definition development stage involved examining systematic reviews and meta-analyses focused on clinical pathways, care plans, critical pathways (and other similar concepts) to assess how these constructs are currently defined in existing literature. Following the completion of this first stage, an initial definition was drafted and feedback was obtained through widespread consultation via a panel of key experts in cancer care, which included healthcare providers, administrators/management and researchers from across the core disciplines represented in the continuum of cancer care (i.e., primary care, nursing, and oncology). Following the working group consultation an integrated care plan for cancer patients was defined as a:

  1. Structured plan of care that engages two or more providers (multi-disciplinary) or is being used in two or more settings that,
  2. Involves care planning longitudinally within or across the stages of cancer (i.e., survivorship, palliative etc.), and
  3. Outlines specific steps/elements of care/mechanisms, with the goal of improving patient, family and/or provider experience, and enabling greater efficiency in care delivery.

Following the development and validation of this definition for an integrated care plan by the expert panel, a scoping review was conducted to explore the core components, drivers for uptake, and key outcome measurement approaches involved in the evaluation of integrated care plans for cancer patients. The use of the term ‘integrated care plans’ for this review stems from the focus of this scoping review on cancer patients specifically. The term ‘care plans’ and ‘care planning’ are commonly used in both grey and peer-reviewed literature pertaining to the management of cancer patients [22, 23, 24, 25]. The overall concept of care planning, and terms such as ‘advanced care planning’ and ‘care planning for end of life’, have a strong grounding in cancer literature [26, 27, 28]. As such the term ‘integrated care plan’ was seen as an appropriate choice to describe the organization and delivery of care for this particular patient population.

Key search terms included care map, clinical pathway, care pathway, care plans, patient care planning, critical path/pathway, individualized care plans, patient care plans, advance care planning, or patient care conferences, and cancer or neoplasms, in Medline, CINAHL, Embase, PubMed and HealthStar between March 1995 and March 2015.

All study designs were included since scoping reviews do not examine study quality [21]. The following inclusion and exclusion criterion were applied to retrieved articles:

Articles were included if the:

  • Description of the integrated care plan, care/clinical pathway/protocol (or similar terms) maps onto the integrated care plan definition that has been validated by the expert panel.
  • Integrated care plan was being used to manage care in adults with cancer (all disease sites were included).
  • Integrated care plan was initiated following a cancer diagnosis (screening and prevention were considered to be out of scope for this review).
  • Article reported on either the development process and outcomes and/or barriers and facilitators associated with integrated care plan development and/or uptake.

Articles were excluded if:

  • There was no clear definition for the integrated care plan, care/clinical pathway/protocol (or similar terms) or the definition did not align with the proposed definition developed by the expert panel.
  • The integrated care plan was not focused exclusively on organizing and delivering care for cancer patients or involved caring for children/youth with cancer.
  • Neither outcomes nor barriers or facilitators were reported on.

Level 1 (title and abstract search) and Level 2 (full-text review) screening was conducted by two independent reviewers (AIK and EA). The data extraction tool was developed and refined by the research team following a testing phase conducted by AIK, EA and VK. Common themes around the key components, facilitators and barriers, and outcome measurement approaches were examined via a thematic analysis [29] using NVIVO (Version 11), which involved exploring emerging and recurrent themes observed across included studies [29]. Open coding was used to develop initial codes based on common ideas emerging from the extracted data. Following a refinement of the coding schema, key themes were organized into a conceptual framework. The steps guiding the conduct of this review are based on existing methodological recommendations around conducting scoping reviews [21, 30] and are summarized in Table 1.

Table 1

Key stages and procedures used in conducting this scoping review.

Stage Description

1. Clarifying purpose and identifying research questions • Key research questions were shared with the expert panel and questions were refines to balance breadth with feasibility
2. Identifying relevant studies • Development and refinement of search strategies and selection of databases
• Testing and refinements of inclusion and exclusion criterion for screening
3. Study selection • Independent application of screening criterion at two levels – title and abstract review and full article review by two reviewers (AIK and EA)
• Resolution of disagreements by a third reviewer (VK) to determine final inclusion/exclusion
4. Data extraction • Development, testing and application of the data extraction tool
5. Data analysis • Summarizing descriptive characteristics of included articles
• Thematic analysis of extracted data and assessing the implications of findings for future research and policy changes
6. Consultation with key stakeholders • Development of a knowledge translation strategy to share the overall conceptual framework and findings with a broad group of stakeholders and experts for further validation


A total of 1061 articles underwent title and abstract review (Level 1 screening), which resulted in 805 articles being excluded. Following Level 1 screening, 256 articles were included for full text review (Level 2 screening), after which 67 articles were retained for data extraction and analysis. Figure 1 provides an overview of the screening and abstraction process.

Figure 1 

Overview of article retrieval, screening and data extraction stages.

Descriptive findings

Broadly five types of integrated care plans have been described, based primarily on the trajectory of cancer care: surgical, systemic, survivorship, palliative and comprehensive. Integrated care plans focused on organizing and delivering care during the surgical stage of cancer care were the most common type of integrated care plan (41.8%), followed by integrated care plans focused on survivorship (35.8%) and palliative (13.4%) stages of the cancer journey. Comprehensive integrated care plans, which included a transition from one stage to another, for example from treatment/surgical intervention into survivorship, represented 7.5% of the total. Only 1 article was focused on systemic treatment (1.5%). Most articles discussed the implementation of a newly developed integrated care plan, but some articles described outcomes associated with the use of an existing integrated care plan including the Journey Forward Care Plan [31] and the LIVESTRONG Care Plan [32] (both of which are focused on survivorship care) as well as the Liverpool Care Pathway [33] which is focused on palliative care.

Integrated care plans were used to manage care across multiple disease sites including breast, esophageal and colorectal cancer, with the largest proportion of integrated care plans focused on breast cancer (26.9%). Some disease sites were grouped for ease of interpretation, specifically the gynecological cancer category includes cervical, ovarian, vaginal and endometrial cancers. Articles originated from a diverse range of countries including both public and private pay systems. About 40% of articles were based in the United States, followed by the United Kingdom (10.4%) and Canada (10.4%). European countries were also well represented in the total sample with integrated care plans from Denmark, Germany, Italy, Netherlands and Sweden.

The medium in which the integrated care plan is delivered, i.e., electronic, paper or combination format, was not indicated for about half of included studies. Approximately 31% of included studies reported the delivery of the plan through a paper medium that providers and sometimes patients had access to, whereas only 9% reported the use of an electronic platform. The combination format ranged from paper copies being posted in the patients’ rooms and an electronic version being added to the patient’s electronic hospital record [34] to patients receiving a partially completed paper copy of their survivorship care plan which is iteratively adjusted over time [35]. Most studies represented a prospective observational design with no control group (37.3%), or a pre and post comparison of outcomes with a control group (31.3%). There were only 8 randomized control trials (11.9%). While study design was not accounted for in assessing articles for inclusion, the two levels of screening involved two authors (AIK and EA) independently verifying if each article met the inclusion criterion that had been validated by the expert panel. The descriptive characteristics of included articles are available in Table 2.

Table 2

Descriptive features of included articles.

Descriptive characteristics Total (n = 67) Relevant articles

Surgical 28 (41.8%) [34, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62]
Survivorship 24 (35.8%) [32, 35, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84]
Palliative 9 (13.4%) [85, 86, 87, 88, 89, 90, 91, 92, 93]
Comprehensive 5 (7.5%) [94, 95, 96, 97, 98]
Systemic 1 (1.5%) [99]
Disease sites
Breast 18 (26.9%) [35, 45, 63, 65, 66, 67, 68, 69, 72, 73, 77, 79, 82, 83, 84, 95, 96, 98]
All 11 (16.4%) [75, 81, 85, 86, 87, 88, 89, 90, 91, 92, 93]
Esophagus 7 (10.4%) [37, 47, 48, 49, 50, 52, 97]
Colorectal 5 (7.5%) [41, 43, 46, 64, 80]
Multiple1 3 (4.4%) [32, 76, 78]
Prostate 4 (6.0%) [44, 58, 62, 94]
Head and Neck 4 (6.0%) [34, 36, 54, 61]
Gynecological2 5 (7.5%) [57, 60, 70, 71, 74]
Gastric, Bladder, Lung, Pancreatic, Brain, Larynx, and Testicular 10 (14.9%) [38, 39, 40, 42, 51, 53, 55, 56, 59, 99]
USA 27 (40.3%) [35, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 93]
UK 7 (10.4%) [46, 47, 48, 49, 72, 92, 98]
Canada 7 (10.4%) [34, 36, 37, 38, 65, 66, 67]
Netherlands 4 (6.0%) [70, 71, 88, 89]
Germany 4 (6.0%) [39, 40, 68, 69]
Denmark, Italy, Australia, Singapore, Belgium, China, Japan, Spain, Sweden, Taiwan, Turkey and Multiple3 18 (26.9%) [32, 41, 42, 43, 44, 45, 63, 64, 85, 86, 87, 90, 91, 94, 95, 96, 97, 99]
Paper 21 (31.3%) [38, 39, 47, 49, 55, 57, 59, 60, 61, 62, 65, 71, 74, 75, 78, 80, 82, 83, 85, 98, 99]
Combination 10 (14.9%) [34, 35, 64, 66, 70, 73, 76, 77, 79, 81]
Electronic 6 (9.0%) [32, 44, 52, 63, 93, 95]
Unclear 30 (44.8%) [36, 37, 40, 41, 42, 43, 45, 46, 48, 50, 51, 53, 54, 56, 58, 67, 68, 69, 72, 84, 86, 87, 88, 89, 90, 91, 92, 94, 96, 97]
Study design
Prospective observational (no control) 25 (37.3%) [35, 41, 50, 52, 53, 56, 58, 62, 63, 64, 66, 72, 73, 75, 76, 77, 78, 79, 80, 84, 95, 96, 97, 98, 99]
Pre and post comparison (with control) 21 (31.3%) [34, 36, 37, 38, 39, 42, 43, 44, 45, 47, 48, 49, 51, 55, 57, 60, 61, 86, 88, 91, 93, 94]
Prospective observational (with control) 13 (19.4%) [46, 50, 53, 54, 59, 69, 81, 82, 85, 89, 90, 92, 95]
Randomized control trial 8 (11.9%) [40, 65, 67, 68, 70, 71, 74, 87]

1Includes two or more disease sites;

2Includes ovarian, cervical, vaginal and/or endometrial cancer;

3The integrated care plan was implemented in multiple countries simultaneously.

Thematic analysis

The key themes that emerged from the thematic analysis are organized into five broad categories:

  1. Design: Inputs associated with the design of integrated care plans.
  2. Components: Core features that were observed across different types of integrated care plans.
  3. Outcome measurement: Indicators/instruments used to measure the impact of integrated care plans.
  4. Facilitators: Key factors that support the design, uptake and implementation of integrated care plans.
  5. Barriers: Challenges associated with the development and use of integrated care plans.

These themes are depicted in the integrated care planning for cancer care framework available in Figure 2.

Figure 2 

Integrated care planning for cancer care framework.

Design features

Multi-disciplinary teams were at the forefront of designing and implementing integrated care plans. Providers from multiple disciplines were engaged to examine gaps in existing care, which then served as the impetus for developing the integrated care plan [60]. Patient involvement in the design phases was quite limited, with only a few studies reporting a targeted effort to engage patients at the outset to better understand and incorporate patient perspectives into plan development [64, 65, 71]. Overall, the development of integrated care plans appeared to be an iterative process; typically involving revisions over time and some type of impact assessment to assess the effectiveness of the integrated care plan [38, 48, 50, 85, 93], which was typically led by a specific team or provider tasked with examining uptake and outcomes [62, 94, 95].

Training for providers/staff on how to use the integrated care plan prior to full-scale implementation was seen as vital to enhancing buy-in around the use of the integrated care plan as a tool to enhance quality of care [34, 64, 82, 85, 86, 87, 91, 93]. Training sessions were often customized to the healthcare team and procedures native to their work environments [47], and conducted through in-person, phone or web-based sessions [82, 86]. Ensuring that the integrated care plan could be adapted to meet evolving patient’s needs [65, 70] and was aligned with operational procedures at the organizational and provider-level also emerged as a common feature of the design phase across the different types of integrated care plans [48, 78, 91, 96].

Having an implementation point of contact, i.e., a provider tasked with supporting plan uptake, was another key design feature of integrated care plans [85]. This typically ranged from a single member of the development team such as a nurse offering onsite supervision for frontline staff [85] to a broader committee tasked with supporting data collection and evaluation efforts [57, 95]. Integrated care plans were often linked to the patient’s electronic medical record and could be reviewed by multiple providers [34, 35, 61, 76, 77]. Information technology capacities to efficiently generate the integrated care plan from the patient’s electronic medical record was another key design element [71, 73, 95], especially in articles that were focused on the survivorship stage of care [70, 71].


Across the various types of integrated care plans, care was organized and delivered by multi-disciplinary teams, involving providers from two or more disciplines. Disciplines represented included physicians, oncologists, surgeons, specialists, and primary care physicians, nurses (including specialist nurses and nurse navigators), pharmacists and allied health professionals such as social workers, speech pathologists, nutritionists/dieticians, as well as respiratory and physical therapists.

An assessment of patient needs was observed across the various types of integrated care plans. Within survivorship care plans, psychosocial distress [70] and quality of life [68, 69] were commonly assessed to help identify psychosocial needs [60] and connect patient’s with appropriate providers, involving either hospital and/or community-based follow-up to obtain nutritional advice, spiritual care and financial counseling [70, 84]. Other types of patient assessments include evaluation by a dietician/nutritionist [50, 52, 84] or speech pathologist (following surgical intervention) [52], or an evaluation of symptoms following treatment or at the end-of-life [50, 63, 85].

The establishment of goals of care that inform activities delivered within the plan was observed in integrated care plans focused on the survivorship or palliative stages of care. Although the nature of goal setting varied considerably. For example, in integrated care plans focused on the palliative stage of care, the provider examines the patient and/or family’s preferences, typically clarifies the goals of care with patients/caregivers, and then generates a treatment plan to align with those preferences [93]. In contrast, goal-setting in the survivorship phase was more focused on behavior and lifestyle change such as better nutrition and exercise to improve long-term health following cancer treatment [35, 77].

Organizing follow-up care post treatment was commonly observed in integrated care plans focused on the surgical and survivorship stages of care. Within integrated care plans focused on surgical care, the emphasis was on short-term recovery from the procedure (i.e., wound care and dietary restrictions) and scheduling post-operative consultations [45, 50, 58, 97]. Whereas among integrated care plans that were focused on survivorship, follow-up care involved educating patients on the appropriate recommendations for future screening, counseling on lifestyle changes, i.e., diet, exercise, smoking cessation, and links to resources for psychosocial, financial and sexual health issues [81].

Across the different types of integrated care plans there was a strong emphasis on the sharing of information within teams (i.e., between staff such as surgeons, nurses and allied health professionals within hospitals) and across organizations e.g., between hospitals and primary care practices involving hospital staff that are coordinating the discharge and transition of care to family physicians. Information exchange via integrated care plans often included aspects such as cancer type/stage, treatment, prognosis, side effects, medication lists prior to discharge, and follow-up care with oncology providers, surgeons and/or family physicians [34, 36, 45, 48, 50, 51, 55, 56, 96]. The nature of information exchange ranged from a summary of the patient’s treatment and symptoms being shared across providers via post, electronically [70, 71, 76, 80, 93], or fax [64] to a comprehensive multi-page plan which included information on symptoms and side effects, psychosocial needs, and community-based supports for the patient as they transition into survivorship [39, 74].

Transitional care planning was another prominent feature especially among integrated care plans focused on the surgical stage of care, and included activities such as discharge planning [36, 48, 52, 60] and referrals to external organizations/providers to manage post-treatment needs [36, 56, 59, 64]. Integrated care plans were often shared with other providers at key transition points – particularly when patients moved from one stage of care to another, specifically from active treatment into survivorship [36, 48, 55, 59, 64, 94].

Symptom or outcome monitoring, i.e., a feedback loop to inform changes to the plan was observed primarily in integrated care plans targeted towards the surgical and palliative stages of care [50, 85, 91, 92, 100], as well as systemic treatment [99]. A strong emphasis on documentation of care, was observed in integrated care plans that were focused on surgical or survivorship stages, as a means to identify gaps in adherence to the plan [59, 62, 65, 77, 85]. This particular aspect of integrated care plans was seen as a useful mechanism in promoting role clarity between different providers over the course of the patient’s journey [60], examining variance in adherence to a specific sequence of care activities [34, 38, 59, 60, 61, 90], and promoting accountability across providers, and between patients and providers [61].

Patient/caregiver engagement by way of involving patients in generating the integrated care plan and accounting for patient (and/or caregiver preferences) featured prominently in plans focused on survivorship and palliative stages [43, 59, 62, 63, 78]. Some studies also reported allowing patients to access the integrated care plan through an electronic or paper format to enable patients to be actively engaged in treatment planning and delivery during their cancer journey [35, 59, 77].

The designation of a key point of contact for patients (during and following treatment) was also observed in some articles [42, 53, 62, 97]. That role was usually held by a nurse who would typically connect with the patient via phone following treatment/discharge from hospital and also arrange follow up care [42, 53, 59, 62, 97]. Patient/caregiver education (oral and written) e.g., self-management support, nutritional counseling, information about homecare, wound care, health promotion (smoking cessation and exercise) [36, 40, 42, 55, 62, 100], and referrals to cancer support groups [64] were other components of integrated care plans – especially those focused on survivorship care.

Outcome measurement

Broadly the outcomes used to assess the impact of integrated care plans can be categorized at three-levels: patient, provider and the system-level outcomes. Patient and system-level indicators were commonly reported whereas only a few studies examined provider-level outcomes.

Measurement approaches for patient-level indicators were typically drawn from validated tools, i.e., Impact of Events Scale [65] and the Short Form 36 Questionnaire [46, 63, 65, 67]. In contrast, outcome measurement was considerably less robust for provider-focused outcomes. Studies that examined provider-level outcomes often did so primarily through a qualitative lens. Examples include assessing provider satisfaction through interviews [66, 78], ascertaining integrated care plan uptake via chart reviews [93], using self-report methods for indicators such as time required to complete the integrated care plan [80]. An overview of the measurement tools used to assess the impact of integrated care plans on patient, provider and system-level outcomes is available in Table 3.

Table 3

Overview of measurement tools used to assess the impact of Integrated Care Plans.

Indicators Measurement tool/instrument


Quality of life • Short Form 36 Questionnaire [45]
• Short Form 12 [46]
• European Organization for Research and treatment of Cancer Quality-of-life questionnaire [46, 64]
Patient satisfaction • Medical Outcomes Study – Patient Satisfaction Questionnaire [65]
• System Usability Scale (modified) [80]
Anxiety/distress • Spielberger State-Trait Anxiety Inventory [45]
• Brief Symptom Inventory [64]
• Cancer Survivors Unmet Needs Scale [64]
• Impact of Events Scale [65]
• Profile of Mood States [65]
• Distress Thermometer [71]
• Patient-Perceived Coordination Index [94]
• Hospital Anxiety and Depression Scale [72]
Caregiver-reported outcomes • Toolkit After-Death Family Member Interview [86]
• Views of Informal Carers Evaluation of Service Survey [86,88)
• Evaluating Care and Health Outcomes for the Dying [92]
• Family Satisfaction Survey [93]

Uptake • Chart reviews/retrospective audit [93]
Workflow – Time to complete care plan • Provider self-report [80]
Provider satisfaction • Telephone interviews [86, 93]
• System Usability Scale (modified) [80]
• Consumer Assessment of Healthcare Providers and Systems Adult Specialty Care Clinician Questionnaire (modified) [80]

Length of stay • Number of nights spent in the hospital after surgery
Post-operative complications • Post-operative complication rates
Mortality • In-hospital mortality
Readmissions • Hospital readmissions
Costs • Total costs of hospital stay
• Total cost of delivering the plan
• Cost-effectiveness (i.e., quality adjusted life years gained for cost incurred)

*Since most system-level indicators represent standardized metrics individual references are not provided.

Commonly observed patient-level outcomes included patient satisfaction, cancer-related distress, patient perceptions of care coordination, patient-reported provider knowledge around the effects of cancer on survivors, perceived knowledge about survivorship [82] and Health-related Quality of Life. Caregiver experience was often examined as an outcome indicator for integrated care plans focused on the palliative stage of care [87, 92]. Provider-level outcomes included provider satisfaction with the use of integrated care plans, i.e., workflow interruptions, ease of use, time associated with generating or discussing the integrated care plan with patients [74, 83], and provider’s perceptions of benefits (i.e., improvements in information sharing between providers) [71, 74, 79, 80, 83, 98]. System-level indicators included common healthcare utilization measures such as length of stay, complication rates (post-operative), hospital readmissions, and cost (hospital-related costs and the cost of delivering the integrated care plan) [36, 39, 40, 41, 43, 46, 47, 48, 49, 51, 54, 55, 56, 57, 58, 60, 61, 67, 85, 95].

At a patient-level, the impact of integrated care plans was fairly mixed. Some studies reported improvements in patient satisfaction [45, 52, 60, 82, 95], patient involvement and patient-reported anxiety (at discharge) [45]. Whereas, no statistically significant differences were observed in cancer-related stress/distress [65], quality of life, and patient satisfaction [65, 74], pre-operative anxiety levels [45] and Health-related Quality of Life [46]. Other trends included improvements in patient awareness about their cancer treatment and side-effects [74, 83, 98], knowing which provider is responsible for follow-up care, and greater patient involvement in managing end-of life care (specifically around the decision to use potentially life-shortening drugs to alleviate symptoms) [89]. One article found statistically significant improvements in patient perceptions around coordination between providers following the use of an integrated care plan to improve survivorship care, but no change in the extent to which the integrated care plan affected how providers understood a patient’s medical history and its implications on their quality of life [82].

At the provider-level, there were self-reported improvements in provider capacity to better manage their patients, specifically in the context of symptom burden [88, 90, 91, 93, 95], and better communication between providers [35, 70, 73]. Since provider-level measures were seldom reported and typically did not involve the use of standardized indicators, trends in provider-level outcomes could not be examined across articles.

System-level indicators were measured primarily in integrated care plans that focused on the surgical phase of care. Overall, general trends around changes in outcomes following the use of integrated care plans revealed improvements in system-level indicators, in particular decreased length of stay [34, 36, 37, 38, 41, 42, 44, 46, 47, 50, 57, 60, 61, 62], reduced costs (direct costs associated with hospital stay) [34, 38, 39, 42, 44, 57, 60, 62, 95], decreased post-operative complication and lower readmission rates [41, 55] or no change in costs [58]. One study found that the use of the integrated care plan was associated with a small increase in costs (with total quality-adjusted life years being almost equivalent between the intervention and control group) [67].

Several articles reported on the use of an existing care plan – primarily the LIVESTRONG, Journey Forward or Liverpool Care Plan respectively. Most study designs involving the Liverpool Care Pathway were either randomized control trials or had a comparable control group. One study reported statistically significant improvement in the extent to which patients were treated with respect, kindness and dignity, and the degree to which family emotional support, family self-efficacy, and coordination of care, but found no significant improvements in symptom control [86]. Whereas other studies indicated no differences in outcomes between patients cared for using the Liverpool Care Pathway and controls [87, 92]. Other trends involving the Liverpool Care Pathway included a decrease in patients receiving potentially life-shortening drugs to alleviate symptoms [89], and reductions in uncontrolled symptoms at death [91].

Findings associated with the LIVESTRONG Care Plan were mixed. One article reported no changes in patient-reported distress, quality of life, and patient satisfaction [74], while another indicated over 90% of users reporting that the information provided by the integrated care plan was excellent, very good, or good (n = 276), with a further 60% of users reporting that the plan offered information that had not been offered by providers (n = 186), and 61% of users reported that the plan had enabled them to be more engaged with their healthcare team [32]. A majority of users also indicated that the LIVESTRONG Care Plan had increased their knowledge of potential long-term impacts of their cancer and what follow-up tests were required as they enter the survivorship phase [32].

For the Journey Forward Care Plan – one study reported that a majority of respondents found the plan to be very useful [78]. And in a second study among patients with breast cancer, over 70% of patients (n = 36) reported that the plan provided clarity around the importance of follow-up visits to check for late effects of cancer treatment, and helped them to better understand the value of engaging in health-promotion behaviors following treatment [76].


Key facilitators that enable and support the development and on-going use of integrated care plans were conceived to occur at three levels:

  1. Micro: Patient and provider-level factors that support integrated care plan development and uptake
    Provider involvement in plan development and buy-in was a crucial facilitator [57, 84, 90, 91, 94], by way of helping to foster a sense of ownership and accountability over the integrated care plan’s value [57]. Engaging a diverse range of providers during the development phase may help ensure that the plan is customized to existing workflows and variations in scope of practice across provider disciplines, and supports greater transparency in role clarity and accountability between providers. Moreover, involving patients and caregivers as a means to empower them as participants in their own care to promote transparency between patients and providers was also highlighted as an important enabler [64].
  2. Meso: Structural or process elements at the organizational level
    A dedicated provider or team that oversees integrated care plan development and implementation by serving as a conduit between providers and organizational management, and advocates for plan uptake was described as an important facilitator [57, 62, 85, 86]. Information technology capacities to enable patients and providers to access the integrated care plan [73, 78, 93] and the alignment of integrated care plan use with existing workflows also served as important meso-level facilitators.
  3. Macro: Policy-level factors that support the design and uptake of integrated care plans
    National oncological care policies that establish or promote standards around treatment guidelines and care management provide a yardstick for quality around patient care [96] and create a supportive environment for plan uptake. Other macro-level facilitators included incentivizing uptake by minimizing administrative barriers (i.e., process of reimbursement for plan use) that providers may face in trying to promote the integrated care plan as the standard of care [77, 80].


The barriers associated with use of integrated care plans originated mostly at the provider level and included most prominently limited provider buy-in and a lack of physician leadership [39, 93]. In one study, the lack of provider buy in was attributed to medical education, specifically that palliative care is not part of undergraduate medical training in Italy, so physicians may not consider arranging palliative care to be within their scope of practice [87]. Other challenges included provider reluctance (and the learning curve) associated with adopting a new approach towards organizing care and misalignment between activities in the plan and existing workflows [63, 85, 93], Staff turnover also inhibited integrated care plans from becoming embedded in workflows as the standard of practice [59, 94, 95].

Inadequate information technology support, specifically limited functionality of the electronic medical record in generating an integrated care plan for survivorship care was an important barrier due to the time and resource costs associated with providers manually entering items from the health record rather than an automated transfer [79]. In addition, difficulties in accessing integrated care plans from medical records across organizations [63], limited co-location of providers, and inadequate financial compensation for using integrated care plans [64, 73, 78, 80] were among other reported barriers to use [63].


While there is a growing emphasis on the use of care plans to guide the organization and delivery of care for cancer patients, our understanding of the components and key facilitators of integrated care plan uptake is still in its early stages. This review was unable to identify a single integrated care plan that spanned across all stages of the cancer journey from diagnosis through to survivorship or palliative care. From the articles that were included, most integrated care plans appear to be focused on a single stage. Integrated care plans that span across two stages of the cancer journey (i.e., surgical to survivorship care) represent less than 10% of included articles, indicating that transitions of care have not heavily featured as a core attribute of integrated care delivery for cancer patients, and that this gap requires further exploration [1]. Most of the integrated care plans reviewed were focused on the surgical stage of care, which reflects a general trend around the use of care planning methodologies to primarily guide clinical practice (typically in acute care settings) rather than being employed across healthcare settings along the continuum of care for a specific patient group or illness [101, 102, 103]. The disproportionate use of integrated care plans for surgical stages of care is in line with a historically strong emphasis on using clinical outcomes to assess the impact of integrated care plans, clinical pathways etc., observed in current literature [18, 101, 102, 103]. And in fact, Van Herck et al. found that clinically-oriented outcomes were assessed in 65.5% of articles they reviewed in assessing the effectiveness of clinical pathways, whereas team and service effects received considerably less attention [18].

Similarities were however noted across the different types of integrated care plans included in this review in terms of the design features and core components observed, indicating the potential to leverage these shared elements to create an integrated care plan that spans across stages of the cancer journey, including key transition points [1, 3].

The adoption of an integrated care plan to guide the delivery of care relies heavily on provider uptake and training on how to use the integrated care plan [34, 39, 43, 60, 61, 75, 94]. The upstream involvement and continuous engagement of providers during plan development and evaluation were considered core elements of the design phase [38, 39, 60]. Provider training, oversight from a dedicated provider-based committee and program champions have been previously recognized as important facilitators for the uptake and on-going use of integrated care plans or clinical pathways (and related concepts) in other studies [104, 105].

Many elements of the integrated care plan development process, including a clear identification of a target population, multi-disciplinary development, sequencing of care activities, and staff training map onto key elements of existing pathway development methodology [104, 106]. However this formal process/approach towards plan development was not always clearly articulated in the articles included in this review.

Many of the patient-level metrics reported across articles reflect indicators and instruments that are increasingly categorized as patient-reported outcome measures in cancer care, including the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Brief Symptom Inventory, Functional Assessment of Cancer Therapy-G, Profile of Mood States, and the Distress Thermometer [107]. Interestingly, while integrated care plans are intended to be patient-facing, patient engagement in the development phase was reported by only a handful of articles [64, 65, 71]. This disconnect highlights the need to involve patients at the outset of plan development, since integrated care plans are intended to be patient-facing tools, particularly in light of growing emphasis on patient engagement and the inclusion of patient-reported outcomes in assessing the quality of cancer care more recently [107, 108, 109, 110, 111].

Compared to patient and system-level indicators, outcome measurement at the provider level was less robust, with only a handful of studies reporting on provider experiences with using integrated care plans to deliver care. Since providers are core end-users of integrated care plans, uptake relies heavily on provider commitment, and it is surprising to see a prominent gap in the assessment of provider-focused outcomes across different types of integrated care plans included in this review. In addition, findings also revealed limited reporting on process indicators, highlighting the need for greater attention towards developing indicators intended to help understand how integrated care plans affect team functioning (within and across healthcare settings) and inform the operational aspects of care delivery as it relates to cancer care.

System-level outcome trends emerging mainly from integrated care plans focused on surgical treatment indicate reductions in length of stay [34, 36, 37, 38, 42, 46, 47, 50, 57, 61, 62], costs (direct costs associated with hospital stay) [34, 38, 39, 42, 57, 62, 95] and post-operative complication rates [55]. Changes in patient-level outcomes were mixed; some studies indicated improvements in patient satisfaction [45, 60, 82, 95] and patient-reported anxiety [45], whereas others report no statistically significant differences in indicators such as cancer-related stress] [65] and Health-related Quality of Life [46]. Since study quality is not accounted for in scoping reviews it is not possible to draw reliable conclusions around the outcomes of integrated care plans from the trends observed. Overall the current state of knowledge around the outcomes associated with care plans for cancer patients is still in its early stage [22]. More work is needed to advance our understanding of the short and long-term outcomes associated with using integrated care plans to support the organization and delivery of care for cancer patients.


One of the key limitations of this work is the restricted extent to which generalizations can be made about the impact of integrated care plans in terms of patient, provider and system-level outcomes. Since study quality including sample size and study design was not accounted for, findings represent a description of broad themes observed across articles. In addition the absence of a common and generally accepted definition of an integrated care plan, and a lack of consensus around the attributes of integrated care delivery as it pertains to cancer care, may have narrowed the breadth of articles that were captured in this review. Nonetheless, efforts were made to ensure that the search terms used to guide this scoping review enabled us to capture a wide range of constructs, and the search strategy was validated by the project team and with an external librarian.

Another limitation is the inclusion of articles that involved the development and pilot testing of an integrated care plan, as long as the outcomes associated with pilot-testing were discussed in the article, which may not reflect the outcomes or challenges associated with full-scale implementation. In addition, authors often did not report on key operational details (e.g., organizational inputs or process measures etc.) associated with developing and/or implementing integrated care plans. And most studies did not report on patient characteristics (aside from site and stage), thereby the complexity of the patient population including multi-morbidity, socio-economic status, and caregiver support, and its potential impact on the uptake and effectiveness of integrated care plans is hard to quantify.


Findings indicate that an integrated approach to care delivery over the course of the cancer journey is still in its early stages. Similarities in design features, core components and key facilitators across the various types of integrated care plans highlight an opportunity to leverage these shared features to move towards developing integrated care plans that span the course of a patient’s cancer journey, rather than a phase-specific silo approach that currently dictates the way care is delivered.

Multi-disciplinary teams, iterative development, patient needs assessment, and transitional planning emerged as key features of integrated care plans for cancer patients. Gaps in information technology support, limited physician buy-in as well as time and resource intensity were identified as key barriers to plan uptake, and must be considered at the outset of plan development. In terms of outcome measurement, patient and system-level indicators were robustly assessed, whereas provider-level metrics were less commonly explored and typically did not involve the use of a validated measurement instruments etc. Further exploring how outcomes vary across disease sites and patient sub-groups, and expanding our knowledge base around measuring patient and provider-level outcomes are important next steps to consider. Future work on this topic is warranted, in particular validating the conceptual framework through broader expert consensus, and developing and piloting an integrated care plan in partnership with providers, patients and administrators that work in the cancer system along with other key stakeholders including primary and community care providers.


Prof. Dr. Geert Goderis, Associate Professor, Academic Centre for General Practice, KU Leuven, Leuven, Belgium.

Jan F Nygård, PhD, CIO/Head of the Registry Informatics Department, The Cancer Registry of Norway.

Ana Rodríguez Cala, Director of Strategy and Projects, Institut Català d’Oncologia (Catalan Institute of Oncology).

Competing Interests

The authors have no competing interests to declare.


  1. Evans, J Matheson, G Buchman, S MacKinnon, M Meertens, E Ross, J et al. (2014). Integrating Cancer Care Beyond the Hospital and Across the Cancer Pathway: A Patient-Centred Approach. Healthcare Quarterly Dec 23 201417(SP): 28–32.  

  2. Trosman, JR Carlos, RC Simon, MA Madden, DL Gradishar, WJ Benson, AB et al. (2016). Care for a Patient With Cancer As a Project: Management of Complex Task Interdependence in Cancer Care Delivery. J Oncol Pract, Aug 30 2016DOI: 

  3. Wodchis, W, Arthur, E, Khan, AI, Gandhi, S, MacKinnon, M and Sussman, J (2016). Cost trajectories for cancer patients. Current oncology (Toronto, Ont) 23(1)DOI: 

  4. Ko, C and Chaudhry, S (2002). The Need for a Multidisciplinary Approach to Cancer Care. Journal of Surgical Research Jun 1 2002105(1): 53–7, DOI: 

  5. Kattlove, H and Winn, RJ (2003). Ongoing care of patients after primary treatment for their cancer. CA Cancer J Clin Jun 200353(3): 172–96, DOI: 

  6. Vanhaecht, K, Panella, M, Zelm, R and van Sermeus, W (2010). An overview on the history and concept of care pathways as complex interventions. International Journal of Care Pathways Sep 1 201014(3): 117–23, DOI: 

  7. De Bleser, L, Depreitere, R, De Waele, K, Vanhaecht, K, Vlayen, J and Sermeus, W (2006). Defining pathways. J Nurs Manag Oct 200614(7): 553–63, DOI: 

  8. Baker, JN Hinds, PS Spunt, SL Barfield, RC Allen, C Powell, BC et al. (2008). Integration of Palliative Care Practices into the Ongoing Care of Children with Cancer: Individualized Care Planning and Coordination. Pediatric Clinics of North America Feb 200855(1): 223–50, DOI: 

  9. Mayer, DK, Nekhlyudov, L, Snyder, CF, Merrill, JK, Wollins, DS and Shulman, LN (2014). American Society of Clinical Oncology Clinical Expert Statement on Cancer Survivorship Care Planning. Journal of Oncology Practice Nov 1 201410(6): 345–51, DOI: 

  10. Michael, N O’Callaghan, C Clayton, J Pollard, A Stepanov, N Spruyt, O et al. (2013). Understanding how cancer patients actualise, relinquish, and reject advance care planning: implications for practice. Support Care Cancer Aug 201321(8): 2195–205, DOI: 

  11. De Vries, M, van Weert, JCM, Jansen, J, Lemmens, VEPP and Maas, HAAM (2007). Step by step development of clinical care pathways for older cancer patients: necessary or desirable?. Eur J Cancer Oct 200743(15): 2170–8, DOI: 

  12. Vanhaecht, K Bollmann, M Bower, K Gallagher, C Gardini, A Guezo, J et al. (2006). Prevalence and use of clinical pathways in 23 countries – an international survey by the European Pathway Association. Journal of Integrated Pathways Apr 1 200610(1): 28–34, DOI: 

  13. Panella, M (). Reducing clinical variations with clinical pathways: do pathways work?. International Journal for Quality in Health Care 15(6): 509–21, DOI: 

  14. Panella, M, Van, ZR, Sermeus, W and Vanhaecht, K (2012). Care pathways for the organization of patients’ care. beoih 28(2): 111–22, DOI: 

  15. Rotter, T Kinsman, L James, E Machotta, A Gothe, H Willis, J et al. (2010). Clinical pathways: effects on professional practice, patient outcomes, length of stay and hospital costs. Cochrane Database Syst Rev 3: CD006632.DOI: 

  16. Kinsman, L, Rotter, T, James, E, Snow, P and Willis, J (2010). What is a clinical pathway? Development of a definition to inform the debate. BMC Medicine May 27 20108(1): 31.DOI: 

  17. Dykes, PC Samal, L Donahue, M Greenberg, JO Hurley, AC Hasan, O et al. (2014). A patient-centered longitudinal care plan: vision versus reality. J Am Med Inform Assoc Nov 201421(6): 1082–90, DOI: 

  18. Van Herck, P, Vanhaecht, K and Sermeus, W (2004). Effects of clinical pathways: do they work?. Journal of Integrated Care Pathways Dec 20048(3): 95–105, DOI: 

  19. Bao, H Yang, F Su, S Wang, X Zhang, M Xiao, Y et al. (2016). Evaluating the effect of clinical care pathways on quality of cancer care: analysis of breast, colon and rectal cancer pathways. J Cancer Res Clin Oncol May 2016142(5): 1079–89, DOI: 

  20. Mayer, DK, Birken, SA, Check, DK and Chen, RC (2015). Summing it up: An integrative review of studies of cancer survivorship care plans (2006–2013). Cancer Apr 1 2015121(7): 978–96, DOI: 

  21. Arksey, H and O’Malley, L (2005). Scoping studies: towards a methodological framework. International Journal of Social Research Methodology Feb 1 20058(1): 19–32, DOI: 

  22. Parry, C, Kent, EE, Forsythe, LP, Alfano, CM and Rowland, JH (2013). Can’t See the Forest for the Care Plan: A Call to Revisit the Context of Care Planning. J Clin Oncol Jul 20 201331(21): 2651–3, DOI: 

  23. Ganz, PA (2008). Ensuring Quality Care for Cancer Survivors: Implementing the Survivorship Care Plan. Seminars in Oncology Nursing Aug 1 200824(3): 208–17, DOI: 

  24. Walling, A Lorenz, KA Dy, SM Naeim, A Sanati, H Asch, SM et al. (2008). Evidence-Based Recommendations for Information and Care Planning in Cancer Care. JCO Aug 10 200826(23): 3896–902, DOI: 

  25. Mayer, DK, Nekhlyudov, L, Snyder, CF, Merrill, JK, Wollins, DS and Shulman, LN (2014). American Society of Clinical Oncology clinical expert statement on cancer survivorship care planning. J Oncol Pract Nov 201410(6): 345–51, DOI: 

  26. Balogh, EP, Ganz, PA, Murphy, SB, Nass, SJ, Ferrell, BR and Stovall, E (2011). Patient-Centered Cancer Treatment Planning: Improving the Quality of Oncology Care. Summary of an Institute of Medicine Workshop. Oncologist Dec 201116(12): 1800–5, DOI: 

  27. Smith, AK McCarthy, EP Paulk, E Balboni, TA Maciejewski, PK Block, SD et al. (2008). Racial and Ethnic Differences in Advance Care Planning Among Patients With Cancer: Impact of Terminal Illness Acknowledgment, Religiousness, and Treatment Preferences. JCO Sep 1 200826(25): 4131–7, DOI: 

  28. True, G, Phipps, EJ, Braitman, LE, Harralson, T, Harris, D and Tester, W (2005). Treatment preferences and advance care planning at end of life: The role of ethnicity and spiritual coping in cancer patients. Annals of Behavioral Medicine Oct 200530(2): 174–9, DOI: 

  29. Mays, N, Pope, C and Popay, J (2005). Systematically reviewing qualitative and quantitative evidence to inform management and policy-making in the health field. J Health Serv Res Policy Jul 200510(Suppl 1): 6–20, DOI: 

  30. Levac, D, Colquhoun, H and O’Brien, KK (2010). Scoping studies: advancing the methodology. Implementation Science Sep 20 20105(1): 69.DOI: 

  31. National Coalition for Cancer Survivorship (2017). Journey Forward [Internet]. NCCS – National Coalition for Cancer Survivorship, [cited 2017 Jun 15]. Available from: 

  32. Hill-Kayser, CE, Vachani, CC, Hampshire, MK, Di Lullo, G, Jacobs, LA and Metz, JM (2013). Impact of internet-based cancer survivorship care plans on health care and lifestyle behaviors. Cancer Nov 1 2013119(21): 3854–60, DOI: 

  33. National Health Service Choices (2015). News analysis: What is the Liverpool Care Pathway?. Health News – NHS Choices [Internet], [cited 2015 Dec 17]. Available from: 

  34. Yeung, JK Dautremont, JF Harrop, AR Asante, T Hirani, N Nakoneshny, SC et al. (2014). Reduction of pulmonary complications and hospital length of stay with a clinical care pathway after head and neck reconstruction. Plast Reconstr Surg Jun 2014133(6): 1477–84, DOI: 

  35. Trotter, K, Frazier, A, Hendricks, CK and Scarsella, H (2011). Innovation in survivor care: group visits. Clin J Oncol Nurs Apr 201115(2)DOI: 

  36. Dautremont, JF Rudmik, LR Yeung, J Asante, T Nakoneshny, SC Hoy, M et al. (2013). Cost-effectiveness analysis of a postoperative clinical care pathway in head and neck surgery with microvascular reconstruction. J Otolaryngol Head Neck Surg 42DOI: 

  37. Lee, L Li, C Robert, N Latimer, E Carli, F Mulder, DS et al. (2013). Economic impact of an enhanced recovery pathway for oesophagectomy. Br J Surg Sep 1 2013100(10): 1326–34, DOI: 

  38. Sherman, D, Matthews, TW, Lampe, H and LeBlanc, S (2001). Laryngectomy clinical pathway: development and review. J Otolaryngol Apr 200130(2): 115–20, DOI: 

  39. Schwarzbach, M, Rössner, E, Schattenberg, T, Post, S, Hohenberger, P and Ronellenfitsch, U (2010). Effects of a clinical pathway of pulmonary lobectomy and bilobectomy on quality and cost of care. Langenbecks Arch Surg Feb 21 2010395(8): 1139–46, DOI: 

  40. Muehling, BM Halter, GL Schelzig, H Meierhenrich, R Steffen, P Sunder-Plassmann, L et al. (2008). Reduction of postoperative pulmonary complications after lung surgery using a fast track clinical pathway. Eur J Cardiothorac Surg Jul 200834(1): 174–80, DOI: 

  41. Feroci, F Lenzi, E Baraghini, M Garzi, A Vannucchi, A Cantafio, S et al. (2013). Fast-track surgery in real life: how patient factors influence outcomes and compliance with an enhanced recovery clinical pathway after colorectal surgery. Surg Laparosc Endosc Percutan Tech Jun 201323(3): 259–65, DOI: 

  42. So, JBY, Lim, ZL, Lin, H-A and Ti, T-K (2008). Reduction of hospital stay and cost after the implementation of a clinical pathway for radical gastrectomy for gastric cancer. Gastric Cancer 11(2): 81–5, DOI: 

  43. Soria-Aledo, V Mengual-Ballester, M Pellicer-Franco, E Carrillo-Alcaraz, A Cases-Baldó, MJ Carrasco-Prats, M et al. (2011). Evaluation of a clinical pathway to improve colorectal cancer outcomes. Am J Med Qual Oct 201126(5): 396–404, DOI: 

  44. Hsu, Y-C, Tsui, K-H, Chen, C-L, Lee, S-H, Wu, Y-S and Chang, P-L (2008). Web-based clinical pathway for reducing practice variations in radical prostatectomy. Chang Gung Med J Dec 200831(6): 567–75.  

  45. Tastan, S, Hatipoglu, S, Iyigun, E and Kilic, S (2012). Implementation of a clinical pathway in breast cancer patients undergoing breast surgery. European Journal of Oncology Nursing Sep 1 201216(4): 368–74, DOI: 

  46. Khan, SA Ullah, S Ahmed, J Wilson, TR McNaught, C Hartley, J et al. (2013). Influence of enhanced recovery after surgery pathways and laparoscopic surgery on health-related quality of life. Colorectal Dis Jul 201315(7): 900–7, DOI: 

  47. Tang, J, Humes, D, Gemmil, E, Welch, N, Parsons, S and Catton, J (2013). Reduction in length of stay for patients undergoing oesophageal and gastric resections with implementation of enhanced recovery packages. Ann R Coll Surg Engl Jul 201395(5): 323–8, DOI: 

  48. Preston, SR, Markar, SR, Baker, CR, Soon, Y, Singh, S and Low, DE (2013). Impact of a multidisciplinary standardized clinical pathway on perioperative outcomes in patients with oesophageal cancer. Br J Surg Jan 2013100(1): 105–12, DOI: 

  49. Munitiz, V, Martinez-de-Haro, LF, Ortiz, A, Ruiz-de-Angulo, D, Pastor, P and Parrilla, P (2010). Effectiveness of a written clinical pathway for enhanced recovery after transthoracic (Ivor Lewis) oesophagectomy. Br J Surg May 201097(5): 714–8, DOI: 

  50. Markar, SR, Schmidt, H, Kunz, S, Bodnar, A, Hubka, M and Low, DE (2014). Evolution of standardized clinical pathways: refining multidisciplinary care and process to improve outcomes of the surgical treatment of esophageal cancer. J Gastrointest Surg Jul 201418(7): 1238–46, DOI: 

  51. Nussbaum, DP Penne, K Speicher, PJ Stinnett, SS Perez, A White, RR et al. (2014). The role of clinical care pathways: an experience with distal pancreatectomy. J Surg Res Jul 2014190(1)DOI: 

  52. Cerfolio, RJ, Bryant, AS, Bass, CS, Alexander, JR and Bartolucci, AA (2004). Fast Tracking After Ivor Lewis Esophagogastrectomy. Chest Oct 2004126(4): 1187–94, DOI: 

  53. Prather, SH, Forsyth, LW, Russell, KD and Wagner, VL (2003). Caring for the patient undergoing transsphenoidal surgery in the acute care setting: an alternative to critical care. J Neurosci Nurs Oct 200335(5): 270–5, DOI: 

  54. Yueh, B Weaver, EM Bradley, EH et al. (2003). A critical evaluation of critical pathways in head and neck cancer. Arch Otolaryngol Head Neck Surg Jan 1 2003129(1): 89–95, DOI: 

  55. Chang, SS, Smith, JAJ, Girasole, C, Baumgartner, RG, Roth, BJ and Cookson, MS (2002). Beneficial impact of a clinical care pathway in patients with testicular cancer undergoing retroperitoneal lymph node dissection. J Urol Jul 2002168(1)DOI: 

  56. Chang, SS, Cookson, MS, Baumgartner, RG, Wells, N and Smith, JAJ (2002). Analysis of early complications after radical cystectomy: results of a collaborative care pathway. J Urol May 2002167(5): 2012–6, DOI: 

  57. Ghosh, K Downs, LS Padilla, LA Murray, KP Twiggs, LB Letourneau, CM et al. (2001). The implementation of critical pathways in gynecologic oncology in a managed care setting: a cost analysis. Gynecol Oncol Nov 200183(2): 378–82, DOI: 

  58. Keetch, DW and Buback, D (1998). A clinical-care pathway for decreasing hospital stay after radical prostatectomy. Br J Urol Mar 199881(3)DOI: 

  59. Golden, TM and Ratliff, C (1997). Development and implementation of a clinical pathway for radical cystectomy and urinary system reconstruction. J Wound Ostomy Continence Nurs Mar 199724(2): 72–8.  

  60. Morris, M, Levenback, C, Burke, TW, Dejesus, Y, Lucas, KR and Gershenson, DM (1997). An outcomes management program in gynecologic oncology. Obstet Gynecol Apr 199789(4): 485–92, DOI: 

  61. Cohen, J, Stock, M, Andersen, P and Everts, E (1997). Critical pathways for head and neck surgery. Development and implementation. Arch Otolaryngol Head Neck Surg Jan 1997123(1): 11–4, DOI: 

  62. Koch, MO and Smith, JAJ (1996). Influence of patient age and co-morbidity on outcome of a collaborative care pathway after radical prostatectomy and cystoprostatectomy. J Urol May 1996155(5): 1681–4, DOI: 

  63. Jiwa, M, Longman, G, Sriram, D, Sherriff, J, Briffa, K and Musiello, T (2013). Cancer care coordinator: promoting multidisciplinary care – a pilot study in Australian general practice. Collegian Mar 201320(1): 67–73, DOI: 

  64. Jefford, M Lotfi-Jam, K Baravelli, C Grogan, S Rogers, M Krishnasamy, M et al. (2011). Development and pilot testing of a nurse-led posttreatment support package for bowel cancer survivors. Cancer Nurs Jun 201134(3)DOI: 

  65. Grunfeld, E Julian, JA Pond, G Maunsell, E Coyle, D Folkes, A et al. (2011). Evaluating Survivorship Care Plans: Results of a Randomized, Clinical Trial of Patients With Breast Cancer. JCO Dec 20 201129(36): 4755–62, DOI: 

  66. Haq, R Heus, L Baker, NA Dastur, D Leung, F-H Leung, E et al. (2013). Designing a multifaceted survivorship care plan to meet the information and communication needs of breast cancer patients and their family physicians: results of a qualitative pilot study. BMC Med Inform Decis Mak 13DOI: 

  67. Coyle, D, Grunfeld, E, Coyle, K, Pond, G, Julian, JA and Levine, MN (2014). Cost Effectiveness of a Survivorship Care Plan for Breast Cancer Survivors. JOP Mar 1 201410(2): e86–92, DOI: 

  68. Klinkhammer-Schalke, M Koller, M Steinger, B Ehret, C Ernst, B Wyatt, JC et al. (2012). Direct improvement of quality of life using a tailored quality of life diagnosis and therapy pathway: randomised trial in 200 women with breast cancer. Br J Cancer Feb 28 2012106(5): 826–38, DOI: 

  69. Klinkhammer-Schalke, M Koller, M Wyatt, JC Steinger, B Ehret, C Ernst, B et al. (2008). Quality of life diagnosis and therapy as complex intervention for improvement of health in breast cancer patients: delineating the conceptual, methodological, and logistic requirements (modeling). Langenbecks Arch Surg Jan 2008393(1) 

  70. Ezendam, NPM Nicolaije, KAH Kruitwagen, RFPM Pijnenborg, JMA Vos, MC Boll, D et al. (2014). Survivorship Care Plans to inform the primary care physician: results from the ROGY care pragmatic cluster randomized controlled trial. J Cancer Surviv Dec 20148(4)DOI: 

  71. Nicolaije, KAH, Ezendam, NPM, Vos, MC, Pijnenborg, JMA, van de Poll-Franse, LV and Kruitwagen, RFPM (2014). Oncology providers’ evaluation of the use of an automatically generated cancer survivorship care plan: longitudinal results from the ROGY Care trial. J Cancer Surviv Jun 20148(2): 248–59, DOI: 

  72. Thompson, J Coleman, R Colwell, B Freeman, J Greenfield, D Holmes, K et al. (2014). Preparing breast cancer patients for survivorship (PREP) – A pilot study of a patient-centred supportive group visit intervention. European Journal of Oncology Nursing Feb 201418(1): 10–6, DOI: 

  73. Miller, R (2008). Implementing a Survivorship Care Plan for Patients With Breast Cancer. Clinical Journal of Oncology Nursing Jun 200812(3): 479–87, DOI: 

  74. Brothers, BM, Easley, A, Salani, R and Andersen>, BL (2013). Do survivorship care plans impact patients’ evaluations of care? A randomized evaluation with gynecologic oncology patients. Gynecol Oncol Jun 2013129(3): 554–8, DOI: 

  75. Jackson, JM, Scheid, K and Rolnick, SJ (2013). Development of the cancer survivorship care plan: what’s next? Life after cancer treatment. Clin J Oncol Nurs Jun 201317(3): 280–4, DOI: 

  76. Sprague, BL Dittus, KL Pace, CM Dulko, D Pollack, LA Hawkins, NA et al. (2013). Patient satisfaction with breast and colorectal cancer survivorship care plans. Clin J Oncol Nurs Jun 201317(3): 266–72, DOI: 

  77. Rosales, AR Byrne, D Burnham, C Watts, L Clifford, K Zuckerman, DS et al. (2014). Comprehensive survivorship care with cost and revenue analysis. J Oncol Pract Mar 201410(2): e81–5, DOI: 

  78. Dulko, D Pace, CM Dittus, KL Sprague, BL Pollack, LA Hawkins, NA et al. (2013). Barriers and facilitators to implementing cancer survivorship care plans. Oncol Nurs Forum Nov 201340(6): 575–80, DOI: 

  79. Tevaarwerk, AJ Wisinski, KB Buhr, KA Njiaju, UO Tun, M Donohue, S et al. (2014). Leveraging Electronic Health Record Systems to Create and Provide Electronic Cancer Survivorship Care Plans: A Pilot Study. JOP May 1 201410(3): e150–9, DOI: 

  80. Mayer, DK Gerstel, A Walton, AL Triglianos, T Sadiq, TE Hawkins, NA et al. (2014). Implementing survivorship care plans for colon cancer survivors. Oncol Nurs Forum May 201441(3): 266–73, DOI: 

  81. Donohue, S Sesto, ME Hahn, DL Buhr, KA Jacobs, EA Sosman, JM et al. (2015). Evaluating Primary Care Providers’ Views on Survivorship Care Plans Generated by an Electronic Health Record System. J Oncol Pract, Mar 24 2015DOI: 

  82. Palmer, SC Stricker, CT Panzer, SL Arvey, SA Baker, KS Casillas, J et al. (2015). Outcomes and satisfaction after delivery of a breast cancer survivorship care plan: results of a multicenter trial. J Oncol Pract Mar 201511(2): e222–9, DOI: 

  83. Bulloch, KJ Irwin, ML Chagpar, AB Pusztai, L Killelea, BK Horowitz, NR et al. (2015). Systematic approach to providing breast cancer survivors with survivorship care plans: a feasibility study. J Oncol Pract Mar 201511(2): e170–6, DOI: 

  84. Downs-Holmes, C, Dracon, A, Svarovsky, T and Sustin, M (2014). Development of a survivorship program. Clin J Oncol Nurs Oct 201418(Suppl): 53–6, DOI: 

  85. Lo, S-H Chan, C-Y Chan, C-H Sze, W-K Yuen, K-K Wong, C-S et al. (2009). The implementation of an end-of-life integrated care pathway in a Chinese population. Int J Palliat Nurs Aug 200915(8): 384–8, DOI: 

  86. Costantini, M Pellegrini, F Di Leo, S Beccaro, M Rossi, C Flego, G et al. (2014). The Liverpool Care Pathway for cancer patients dying in hospital medical wards: a before-after cluster phase II trial of outcomes reported by family members. Palliat Med Jan 201428(1): 10–7, DOI: 

  87. Costantini, M Romoli, V Leo, SD Beccaro, M Bono, L Pilastri, P et al. (2014). Liverpool Care Pathway for patients with cancer in hospital: a cluster randomised trial. Lancet Jan 18 2014383(9913): 226–37, DOI: 

  88. Veerbeek, L van Zuylen, L Swart, SJ van der Maas, PJ de Vogel-Voogt, E van der Rijt, CC et al. (2008). The effect of the Liverpool Care Pathway for the dying: a multi-centre study. Palliat Med Mar 200822(2): 145–51, DOI: 

  89. Van der Heide, A, Veerbeek, L, Swart, S, van der Rijt, C, van der Maas, PJ and van Zuylen, L (2010). End-of-life decision making for cancer patients in different clinical settings and the impact of the LCP. J Pain Symptom Manage Jan 201039(1)DOI: 

  90. Veerbeek, L van Zuylen, L Gambles, M Swart, SJ van der Heide, A van der Rijt, CCD et al. (2006). Audit of the Liverpool Care Pathway for the Dying Patient in a Dutch cancer hospital. J Palliat Care Winter 200622(4): 305–8.  

  91. Neo, PSH Poon, MC Peh, TY Ong, SYK Koo, WH Santoso, U et al. (2012). Improvements in end-of-life care with a protocol-based pathway for cancer patients dying in a Singapore hospital. Ann Acad Med Singapore Nov 201241(11): 483–93.  

  92. Mayland, CR, Williams, EMI, Addington-Hall, J, Cox, TF and Ellershaw, JE (2013). Does the “Liverpool Care Pathway” facilitate an improvement in quality of care for dying cancer patients?. Br J Cancer May 28 2013108(10): 1942–8, DOI: 

  93. Luhrs, CA Meghani, S Homel, P Drayton, M O’Toole, E Paccione, M et al. (2005). Pilot of a pathway to improve the care of imminently dying oncology inpatients in a Veterans Affairs Medical Center. J Pain Symptom Manage Jun 200529(6): 544–51, DOI: 

  94. Van Houdt, S, Heyrman, J, Vanhaecht, K, Sermeus, W and De Lepeleire, J (2013). Care pathways to improve care co-ordination and quality between primary and hospital care for patients with radical prostatectomy: a quality improvement project. Qual Prim Care 21(3): 149–55.  

  95. Van Dam, PA Verheyden, G Sugihara, A Trinh, XB Van Der Mussele, H Wuyts, H et al. (2013). A dynamic clinical pathway for the treatment of patients with early breast cancer is a tool for better cancer care: implementation and prospective analysis between. World J Surg Oncol 11 

  96. Gyldenvang, H, Mertz, BG and Ankerson, L (2005). Quality management—improving the clinical pathway for breast cancer patients. European Journal of Oncology Nursing Mar 1 20059(1): 79–82, DOI: 

  97. Viklund, P and Lagergren, J (2007). A care pathway for patients with oesophageal cancer. Eur J Cancer Care (Engl) Nov 200716(6): 533–8, DOI: 

  98. Van Wersch, A, Bonnema, J, Prinsen, B, Pruyn, J, Wiggers, T and van Geel, AN (1997). Continuity of information for breast cancer patients: the development, use and evaluation of a multidisciplinary care-protocol. Patient Educ Couns Feb 199730(2): 175–86, DOI: 

  99. Noie, T, Konishi, T, Nara, S, Ito, K, Harihara, Y and Furushima, K (2003). Development of clinical pathway in S-1 chemotherapy for gastric cancer. Gastric Cancer Apr 20036: 58–65, DOI: 

  100. Thompson, J Coleman, R Colwell, B Freeman, J Greenfield, D Holmes, K et al. (2014). Preparing breast cancer patients for survivorship (PREP) – A pilot study of a patient-centred supportive group visit intervention. European Journal of Oncology Nursing Feb 201418(1): 10–6, DOI: 

  101. Campbell, H, Hotchkiss, R, Bradshaw, N and Porteous, M (1998). Integrated care pathways. BMJ Jan 10 1998316(7125): 133–7, DOI: 

  102. Zander, K (2002). Integrated Care Pathways: eleven international trends. Journal of Integrated Care Pathways 6: 101–7, DOI: 

  103. Kitchiner, D, Davidson, C and Bundred, P (1996). Integrated Care Pathways: effective tools for continuous evaluation of clinical practice. Journal of Evaluation in Clinical Practice 2(1): 65–9, DOI: 

  104. Hyde, E and Murphy, B (2012). Computerized Clinical Pathways (Care Plans): Piloting a Strategy to Enhance Quality Patient Care. Clinical Nurse Specialist 26(5): 277–82, DOI: 

  105. Evans-Lacko, S, Jarrett, M, McCrone, P and Thornicroft, G (2010). Facilitators and barriers to implementing clinical care pathways. BMC Health Services Research Jun 28 201010(1): 182.DOI: 

  106. Vanhaecht, K Gerven, EV Deneckere, S Lodewijckx, C Janssen, I van Zelm, R et al. (2012). The 7-phase method to design, implement and evaluate care pathways. International Journal of Person Centered Medicine Sep 10 20122(3): 341–51.  

  107. Howell, D Molloy, S Wilkinson, K Green, E Orchard, K Wang, K et al. (2015). Patient-Reported Outcomes in Routine Cancer Clinical Practice: A Scoping Review of Use, Impact on Health Outcomes, and Implementation Factors. Ann Oncol, Apr 17 2015DOI: mdv181. 

  108. Jensen, RE Snyder, CF Abernethy, AP Basch, E Potosky, AL Roberts, AC et al. (2014). Review of electronic patient-reported outcomes systems used in cancer clinical care. J Oncol Pract Jul 201410(4): e215–22, DOI: 

  109. Basch, E Snyder, C McNiff, K Brown, R Maddux, S Smith, ML et al. (2014). Patient-Reported Outcome Performance Measures in Oncology. JOP May 1 201410(3): 209–11, DOI: 

  110. Camuso, N, Bajaj, P, Dudgeon, D and Mitera, G (2016). Engaging Patients as Partners in Developing Patient-Reported Outcome Measures in Cancer-A Review of the Literature. Support Care Cancer Aug 201624(8): 3543–9, DOI: 

  111. Warrington, L, Absolom, K and Velikova, G (2015). Integrated care pathways for cancer survivors – a role for patient-reported outcome measures and health informatics. Acta Oncologica May 28 201554(5): 600–8, DOI: